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Is there a way to have the might Roman Empire to fall with Byzantium itself falling to a siege? I realize it might be difficult to think of a empire stretching from the British Isles to Asia Minor falling but that is the challange. I think the best chance might be that they don't make an alliance of convenience with Persia to beat off the Arab invasions. This enabled them to turn back west and reunite Europe under the Roman Empire once again. Of course you could suppose one of the heretics could have succeeded but I think that is far fetched. The vast majority of the population follow the dictates on religion by His Holiness the Patriarch of Constantinople.