DBWI:Anne of Brittany and Louis XII have no male issue

I remember, Isabella of Austria was dowered of Rousillon, Franche Comte and Artois and married the son of Anne of Brittany and Louis XII, Charles IX and Claude of France married Charles V who died in 1522 and had only one child who survived adulthood, Infanta Margarita b. 1521, who married to Ferdinand II of Portugal b. 1523, the son of Catherine of Austria and John III of Portugal, Anne of Brittany delivered Charles IX on autumn 1502, Charles V remarried to Isabella of Portugal after Claude's death.

Charles IX of France was able to convince Henry VIII and the pope to break the union between him and Catherine of Aragon and marry his daughter, Mary of England to his son Louis, the dauphin, the second marriage of Henry VIII with Anne Boleyn was blessed by a son on 1533 named Edward VI, however, Anne Boleyn was burnt at the stake by her husband on 1536 after being discovered as a heretic.

How would history be different if Anne of Brittany fails to bear a son?

@isabella @Kellan Sullivan
 
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I remember, Isabella of Austria was dowered of Rousillon, Franche Comte and Artois and married the son of Anne of Brittany and Louis XII, Charles IX and Claude of France married Charles V who died in 1522 and had only one child who survived adulthood, Infanta Margarita b. 1521, who married to Ferdinand II of Portugal b. 1523, the son of Catherine of Austria and John III of Portugal, Anne of Brittany delivered Charles IX on autumn 1502, Charles V remarried to Isabella of Portugal after Claude's death.

Charles IX of France was able to convince Henry VIII and the pope to break the union between him and Catherine of Aragon and marry his daughter, Mary of England to his son Louis, the dauphin, the second marriage of Henry VIII with Anne Boleyn was blessed by a son on 1533 named Edward VI, however, Anne Boleyn was burnt at the stake by her husband on 1536 after being discovered as a heretic.

How would history be different if Anne of Brittany fails to bear a son?

@isabella @Kellan Sullivan

Obviously Mary Tudor the elder wouldn't assert a restraining hand on her husband, Christian II of Denmark.

Ooc: the son of João III is a born when Katharina's pretty young (she'd only be 16yo), since she only married 2 years later OTL, what changed?
 
Obviously Mary Tudor the elder wouldn't assert a restraining hand on her husband, Christian II of Denmark.

Ooc: the son of João III is a born when Katharina's pretty young (she'd only be 16yo), since she only married 2 years later OTL, what changed?
They have surviving grandchildren via Ferdinand II.
 
Ooc: They were that OTL. Why does her marriage take place earlier here? Karl V obviously still succeeds as king of Spain (based off his and Claude's daughter's title/name), so what makes him let his sister marry earlier here?
That is because Eleanor of Austria ELOPED with the Elector Palatine and married him after seeing the fate of her sister Isabella.
 
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