Cultural WI: Shakespeare's Macbeth killed by a woman?

Lord Macbeth was a loyal general and vassal to the King of Scotland, until three witches stoked his ambition with a prophecy: He will be King, and no man born of woman will harm him. Assured he is invincible, with no small amount of encouragment from his wife, Macbeth seizes the throne and begins a reign of terror, only ended by meeting his own end at the hands of Macduff, born of a caesarean section.

Some might think this twist to the prophecy is somewhat contrived, as J.R.R. Tolkien apparently did when he put in his own story a similar prophecy about the Witch-King, who would not die by the hand of man. He dies by the hand of a woman.

What might've been the effect on English and later world culture had Shakespeare chosen a different end to what might be his most famous work? Perhaps when Macbeth moves to have Macduff killed, he succeeds in catching and killing Macduff but Lady Macduff escapes or survives, motivated to kill Macbeth to avenge her husband and son?
 
My 2c: I'm not sure. Macbeth IIRC plays on the whole inversion that results when the established order is broken (annointed king is murdered and a usurper takes his place instead of his rightful heir). Scotland is plunged into "always night" by the deed and it's only AFTER Macbeth is dead that things go back to "normal". So him killed by a woman would tie in with that.

I imagine Lady MacDuff would be seen as a foil to Lady Macbeth (one kills in the name of ambition and one kills in the name of honour/justice). I mean, Lady Macbeth is ACTUALLY the one who does a lot - she kills the king when Macbeth is too cowardly to do so (the "unsex me" speech comes from that scene doesn't it?) - so it's not unthinkable that Lady MacDuff is equally capable to take justice into her owns hands.
 
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