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Ok, this idea is a bit complicated, but I'll try to explain:

In 1496 the Duke of Savoy - Charles II - died. To keep the Duchy within the male line of the family, the new duke was Philip II the Landless, whose reign would be short, as he would die in 1497. At the time that Philip the Landless became Duke of Savoy he and his sons were the last male members of their ducal family. Philip II had married twice, the first with Margaret of Bourbon, who died in 1483, and the second with Claudine de Brosse, and they would give him four legitimate children.

Margaret gave him one son, Philibert II, who would become the next duke but died childless, and a daughter, Louise, who was married to Charles of Valois-Orleans and would be the mother of Francis I of France.

Claudine gave birth to two sons. The first was the duke Charles III, heir of his half-brother Philibert II, and from whom all the Dukes of Savoy and the later kings of Sardinia and Kings of Italy descend. The other was Philip, and he and his descendants became Dukes of Nemours.

Well, here is the POD: if Claudine had being esterile, denying Philip II new sons, and Philibert II had still died childless in 1504, all the male members of the House of Savoy would be extinct, and the nearest heir of their lands would be the young Francis of Angouleme (the son of Louise of Savoy and Charles of Valois-Orleans). This same boy would become in 1515 King of France, as Louis XII had only daughters. I'm assuming these facts do not change significantly ITTL.

Now, as Savoy was at the time still officially a state of the HRE, would the Habsburgs accept its incorporation into France? There would be any other possible strong claimants? And how could a French Savoy (and Piedmont, as it belonged to the Duchy) affect the Italian Wars (if they still happen ITTL)?
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