Well, a female Conradin won't be charging into Sicily to get captured and killed as a teenager. She'd be a very attractive marriage target though- Duchess of Swabia (assuming that allowed female inheritance?), Queen of Jerusalem (nominally), Queen of Sicily (nominally), something of a claim to the HRE.
In the normal course of events the Emperor/King of Germany would probably try to do something to get her lands/clamp down on the Hohenstaufen claim, but during her lifetime that title is held by the lame duck Richard of Cornwall.
How would a female Conradin effect Manfred's situation in Sicily?