Just a thought I had, but how would the settlement of North America look like if attempts to settle the Eastern Seaboard for one reason or another failed? The Native Confederacies were able to boot out the settlers, the settlers starved, other colonial powers massacred each other, etcetc.
That would leave the major wave of settlement to come up through the South, the Mississippi and the Gulf Coast river deltas. Would England contest for these areas or would English settlers go through private immigration?