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Inspired by this timeline, I've come up with an idea. Their are 2 PODs that will drive this forward. They are:
1- The death of Richard Plantagenet, Duke of Gloucester, in early 1482 during his recapture of Berwick-upon-Tweed. This leaves his young widow Anne Neville (24, turning 25 that year) and his son Edward Plantagenet of Middleham (8, turning 9 that year). The widowed Anne is a highly desirable match for many people and a great landholder in her own right.
2- The birth to a third Princess of Brittany to Francis II of Brittany and Margaret de Foix, named Eleanor. She is healthier than either of her sisters, more robust and sturdier. She is born in 1482, almost to the day Richard Plantagenet died.