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Is it possible for Charles V to wed Anne of Cleves? How'd would this affect the 1540s, the House of Habsburg, France, England and Cleves?

It seems Anne was open to remarrying Henry VIII after Catherine Howard's passing. Charles didn't want to remarry but can we suggest a circumstance that would make him do so w/o killing off his OTL kids?

(I'd previously put forth Amalia but her Lutheran faith makes things less probable)
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