What if, in december 1494, upon his arrival in Rome, Charles VIII had deposed Alexander VI, had put him under arrest, then had replaced him by Della Rovere?
Charles VIII could protect Savoranola in order to counterbalance the power of the Holy See and strenghten his own power over the Papacy.
There could be an earlier Reform.
Without the intrigues of Alexander VI, the formation of the League of Venice would be delayed and Charles VIII would be able to fight the Milaneses and the Venitians in far better conditions than at Fornovo in OTL. Could we see a 'Charles of Valois, King of France and Naples, Duke of Milan' ?