No idea. But, if we work on how she handled Mary II's snubs, Sarah Churchill's defiance, Abigail Masham's obsequiousness, and Elizabeth Percy's attitude towards her, I'd say it's a good thing none of Anne's kids ever made it to teenagers, because I think Anne was someone who avoided conflict when possible, maybe more along the lines of emotional blackmail (tears, tantrums) than let's sit down and talk it out. She strikes me as a very (emotionally) immature woman, who was fine to go along with you as long as your ends were the same, almost dangerously co-dependent on others (Sarah, Abigail). I mean, at Prince George's funeral, Anne's busy whining all the way up the church steps, Sarah turns around to her and screams - in public - "not here!" and Anne lets it slide (Sarah is also the one who forced Anne to leave Windsor after George died, against Anne's wishes). But then, when she sends Sarah packing, the last interview is chilly/frosty (like something out of an encounter with Queen Victoria). Even her early years, Anne formed a close friendship with Sarah because it was what Mary did with Apsley(?).
I'm not sure Anne would be able to handle anyone who had a different opinion to her own. She might resent La Sempre Noiva if that girl has a better relationship with Pedro than Anne does. And perhaps still more because until she (Anne) has a kid, her stepdaughter's the one with the whip hand. But, that said, Luiza Isabel and Anne are close enough in age that they can maybe establish a decent relationship.
Personally, I think Anne was a very lonely person (she wasn't pretty or elegant (or firstborn) like Mary was, and she had problems with her eyesight as a child - not sure if this cleared up later). And anyone who showed her the slightest sliver of affection she clung to - in a very childish way. And that person was her sun, moon and stars for however long (in Sarah's case, nearly all her life) and she was fiercely loyal. But if that person pissed her off, then it was like opening the gates of Hell, because Anne could be a first rate bitch if she wanted to. Sending the Churchills packing - for instance - was almost petty/vindictive in the extreme. Not that Sarah behaved any better - her wake of destruction at Marlborough House when forced to leave (paintings ripped from their frames, marble slabs torn out, mirrors shattered, doors rent from their hinges "like an invading army had been through it" said one contemporary) is hardly her most shining moment.
Sorry, I know I referred a lot to Sarah Churchill and the Marlboroughs, but it's basically the closest relationship I can think of to Anne/Luiza Isabel's (both age wise and friendship wise). It's not like Anne had surviving kids that we can know how she would behave with them. I think another way would be to look at her behaviour with her half-siblings after Mary left and before her own marriage. IDK what her relationship with the Lady Isabella was like, but I'd assume that when James/Mary of Modena were out of the country, big sis Anne was Isabella's guardian/surrogate mother.