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Many American cities have suffered from American deindustrialization, but the worst by far has to be Detroit. If you haven't already seen the images of it from my one Detroit thread, look here. Massive areas of Detroit are literally completely abandoned due to the city losing population, and are being overrun by nature and the elements. And these were perfectly good buildings, too, and in many cases are still in good condition, but are filled with things just abandoned behind like old books and chairs and what not. It's gotten to the point where the city is downsizing itself, or at least proposing that last I heard.
The challenge is to have more cities be like Detroit where the backbone of industry has collapsed to such a degree and people have left to such a degree that all the things that happened to Detroit happen to them on that grave a level.