Challenge: Better North American Natives

With the PoD after Columbus expedition what can be done to improve the OTL situation of the indigenous inhabitant of North America (Aztecs and other Mexican tribes excluded)? Forming their own states and keeping traditional culture (Meiji-like style) would be most welcome.
 
Their biggest problem is their low population after the introduced diseases. The Cherokee for example were well organized land owners with towns and newspapers. However, by the time that they modernized they were dramatically outnumbered by the Americans.

Native American populations either need to rebound faster from the plagues or European settlement of N. America needs to be slower.
 
Their biggest problem is their low population after the introduced diseases. The Cherokee for example were well organized land owners with towns and newspapers. However, by the time that they modernized they were dramatically outnumbered by the Americans.

Native American populations either need to rebound faster from the plagues or European settlement of N. America needs to be slower.
However they were ultimately struck down by the political expansion of European settlers. If there were some actual Indian states, independent from the US, then the natives would have a chance to endure. Maybe a US-screw scenario, in which the British Indian Reserve develops into a confederacy of native states (somewhat similar to princely states in the British Raj)?
 
1) Making the natives more resistant to the European introduced diseases is practically the only way they have any chance to push-back or at least hold onto what they have before contact.

2) Let the Aztecs not be overbearing oppressors that they were OTL. Then their conquered neighbors might be less likely to join up with Cortez to overthrow them.
 
1) Making the natives more resistant to the European introduced diseases is practically the only way they have any chance to push-back or at least hold onto what they have before contact.

2) Let the Aztecs not be overbearing oppressors that they were OTL. Then their conquered neighbors might be less likely to join up with Cortez to overthrow them.

Just reverse the diseases - have the Europeans introduce syphilis to the Americas while they take smallpox back to Europe.
 
Just reverse the diseases - have the Europeans introduce syphilis to the Americas while they take smallpox back to Europe.
That's going to require a POD well before Columbus (the date specified in the OP). Indeed, it would probably require one closer to 12000 years ago.

But yeah, the massive die-offs from disease pretty much crippled Native American ability to resist. You see this directly in the well-documented conquests of New Spain and Peru (where smallpox severely weakened the native states), but you can also see it with the American Southeast, where the advanced, sedentary Mississippian culture collapsed into much smaller tribes by the time of sustained contact.
 
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