Not with a POD in the 20th century.
If you go back farther, you could have Mexico winning the Mexican-American War, keeping it around as a major power. Perhaps you would need a slightly earlier POD in their independence, in order to keep them from falling into a cycle of dictators and corruption. You could also keep together Gran Colombia, which gives you another major power in South America, and have Brazil develop better. Possibly you could have Argentina gain Chile and Uruguay in the War of Independence.