Catherine of Aragon.

Not meaning to overdo it. WI: She had at least 2 or even 3 daughters by Henry VIII instead of just one? How would they have fared, especially under Edward VI? How about marriage prospects and religious convictions?
 
I'm not an expert on Tudor England. But given how it turned out for Mary (the only child of Catherine of Aragon and Henry VIII in OTL), I'll be betting on the same thing happening to her sisters.

However, if Mary had two sisters, this could have a big impact on English history. If things go OTL and Mary becomes Queen of England, her two sisters will be in line for the English throne before Elizabeth.
 
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