Cast: A Confederacy of Dunces (2005)

[Plumber]

Ignatius J. Reilly: John Goodman

 

[MaskedPickle]

In my TL, if I go beyond my first plans...

Director: Steven Soderbergh
Ignatius J. Reilly: Will Ferrell
Myrna Minkoff (if she appears in flashbacks): Rachel McAdams
Irene Reilly: Jacki Weaver
Claude Robichaux: Clint Eastwood
Angelo Marcuso: Matthew Perry
Burma Jones: Samuel L. Jackson
Gus Levy: John Goodman
Lana Lee: Glenn Close

But even I said ITTL that Ferrell played Ignatius, I would switch Ignatius and Gus Levy with great pleasure.

See this in Wikipedia:

A version adapted by Steven Soderbergh and Scott Kramer, and slated to be directed by David Gordon Green, was scheduled for release in 2005. The film was to star Will Ferrell as Ignatius and Lily Tomlin as Ignatius's mother. A staged reading of the script took place at the 8th Nantucket Film Festival, with Ferrell as Ignatius, Anne Meara as his mother, Paul Rudd as Officer Mancuso, Kristen Johnston as Lana Lee, Mos Def as Burma Jones, Rosie Perez as Darlene, Olympia Dukakis as Santa Battaglia and Miss Trixie, Natasha Lyonne as Myrna, Alan Cumming as Dorian Green, John Shea as Gonzales, Jesse Eisenberg as George, John Conlon as Claude Robichaux, Jace Alexander as Bartender Ben, Celia Weston as Miss Annie, Miss Inez & Mrs. Levy, and Dan Hedaya as Mr. Levy.http://en.wikipedia.org/wiki/A_Confederacy_of_Dunces#cite_note-12

 

[Plumber]

Brad Pitt is from New Orleans, but I can't think of a character that would suit him... Gus Levy is too meek.