Napoleon would only be content with the empire expanding ,not contracting or stagnating , at some point he would have been on the march again ,at that point the Allies would have destroyed France once and for all ,in 1814 France was very lucky with the terms issued ,to extend the war in any form if Napoleon would have considered perhaps concentrating on one foe such as England , and defeated Wellington in Spain , then dominating the Med perhaps a longer drawn out conflict could have evolved , perhaps with the capture of Gibraltar , Malta the conflict could have staggered on for a few more years , but at some point if Napoleon still led France the East would have beckoned ?
Napoleon doesn't really have the option of concentrating on just one opponent when multiple opponents that dislike each other are willing to put aside their differences to fight him.
And how the hey is he going to dominate the Mediterranean when the Royal Navy will pwn (best word I can think of) any fleet that somehow slips out of being blockaded?