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Following the more or less failure at the colony of Avalon (Newfoundland) by the 1st Lord Baltimore, George Calvert he returned to England to campaign for support of a Mid Atlantic Colony to King Charles in 1631. This quickly came into conflict with Virginia and the likes of William Claiborne who battled against the Lord Baltimore against setting up a colony in the Chesapeake Bay which they saw as rightfully Virginian.

At one point during this, Charles offered to Calvert the rights of Proprieter Governor for the Province of Carolina but Calvert continued to covet for territory north of the Potomac river which he eventually got-becoming the State of Maryland. Following his death though Virginia would still have designs on Maryland, even fighting Maryland and encouraging a Puritain takeover of the Catholic haven.

Now what if Calvert had accepted Carolina?

From the outset it would be interesting for two map reasons because then likely Virginia would extend up the entire length of the Chesapeake Bay and Carolina would not be split amongst the 'Proprieter Lords' in 1663, instead quite possibly staying as one large colony.

This could mean that Carolina stays a Catholic haven colony if Virginian interests leave them be and continue with colonization along the Chesapeake Bay and northwest. This could even boost the power of the Calvert family in the Americas, butterflys may even let them keep Avalon and not go into a slow decadant crash.
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