Burying the Pomegranate

The death of the queen
On December 16, 1518, Katherine of Aragon on her birthday, would give birth to a daughter, according to Eustace of Chapuys, Queen Katherine had it easy giving birth but the daughter came out of her womb, the daughter would be named as Katherine.

However, fate would not be kind to the fair Queen Katherine as she had pregnancy complications and she would die a week after and she would be buried in Westminster and be survived by her husband Henry VIII for 30 years.
 
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Fate of the two daughters
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Mary Tudor, Queen of Scots and Spain

In 1528 Wolsey's agent Thomas Magnus discussed an idea of Mary Tudor’s marriage to James V of Scotland with the Scottish diplomat Adam Otterburn and this would come to pass in 1532, when Mary Tudor was sixteen, this was Mary Tudor’s first marriage which would be with James V of Scotland, effectively ending the Auld alliance and she would have two surviving daughters, Catherine Stewart (December 16, 1536) and Mary Stewart (December 8, 1542), On 1543, James V would die and leave Mary Tudor a widow and betrothed to Charles V once again as she was expelled from the regency by the prospective husband of Catherine Stewart, Mathew Stewart, duke of Lennox, however the death of Maria Manuela and her child due to a miscarriage in 1544 would mean that Mary Tudor would marry once again to Philip II of Spain but this time she would bear two children, Infante Carlos(June 2, 1548) and Infanta Juana(December 20, 1550), she would die in 1551 of natural causes.

On the spring of 1535, Queen Anne of Bohemia and Hungary would suffer miscarriage a and Ferdinand, Archduke of Austria needed another wife and he would marry Katherine Tudor, the second daughter of Katherine of Aragon and Henry VIII, she is seventeen at the time of the marriage and would have been crowned as the second queen of Bohemia and Hungary as well of Austria, she would give birth to the following children who would be carried into term and survived infancy; Margaret of Austria(February 16, 1536), Barbara of Austria(April 10, 1538), Charles of Austria(June 3, 1540) and Joanna of Austria(January 24, 1543), she would be crowned as Holy Roman Empress consort with her husband Ferdinand I on the abdication of Charles V.
 
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The death of the Zapolya heir
On 1544, John Sigismund, the son of Isabella Jagiellon and John Zapolya would die, forcing Isabella Jagiellon to marry Archduke of Ferdinand of Austria on 1546 who would be given the Duchy of Opole-Raciborz, starting the Opole line of the Habsburgs as the marriage have resulted in the birth of two sons; Ferdinand(June 3, 1547) and Maximilian (June 4, 1553).
 
Beatrice of Portugal
On 1518, after the death of the Queen, Henry VIII would quickly secure a marriage with Infanta Beatrice of Portugal securing another alliance with Spain, but Beatrice would not be fertile and would have only two pregnancies who would survive term and adulthood, Henry, Prince of Wales(January 1524) and Elizabeth Tudor(May 10, 1530) and she is lucky even if she only had one son but Henry would not be entertained by the fact that Queen Beatrice would not give birth to another son, but even her stepdaughter, Mary would fail to give birth to a son as well, so she was relieved by it.

The birth of her son with King Henry would be a celebration, however, what they did not know is that Henry, Prince of Wales would fail to sire a male issue, even if he married Dorothea of Denmark who was fertile when he was young.

On 1519, Charles V would marry Isabella of Portugal as he had seen that Beatrice, her younger sister had married Henry VIII to further his alliance with the English, however, the marriage would take sometime to produce a pregnancy which would produce a surviving child until a son named Philip, Prince of Asturias was born in 1527.
 
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A history of frustrated marriages and a move of Capital and court
On 1518, Francis I would expect that his sister, Marguerite would now be the King of England, however Infanta Beatrice would marry Henry VIII and Marguerite would instead marry Charles III, Duke of Savoy, a marriage that would produce two children, Charles Emmanuel (January 4, 1522) and Maria of Savoy ( May 10, 1534) who would be the third wife of King Philip II of Spain

On 1526, Eleanor of Austria who was about to marry the King of France, however, she would elope with Frederick II of Palatinate and instead a marriage of the King of France’s son, Francis III, Duke of Brittany and Maria, Duchess of Viseu to seal a peace treaty between France and Spain would be made instead and Francis III would remarry to Hedwig of Poland and Francis I would move the court on Lyon in 1536 after the marriage of the Duke of Brittany and Maria of Viseu.

In 1526, Henry II of Navarre would marry Princess Charlotte of France to strengthen the relationship between France and Navarre.
 
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The three daughters of Charles V
On 1519, Charles V would marry Isabella of Portugal as he had seen that Beatrice, her younger sister had married Henry VIII to further his alliance with the English, however, the marriage would take sometime to produce a surviving child until a daughter named Maria of Spain in June 25, 1525 was born, followed by a son named Philip on May 21, 1527, followed by two daughters, Catherine(December 2, 1528) and Joanna(June 26, 1535).

Catherine is intended for Afonso of Portugal the first son of the King of Portugal to further the matrimonial link between the Portuguese and the Spanish in the long run and Maria is to marry the eldest son of the Holy Roman Emperor and Joanna is intended for a marriage treaty, those were the fates of the three daughters of Charles V.
 
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On 1519, Charles V would marry Isabella of Portugal as he had seen that Beatrice, her younger sister had married Henry VIII to further his alliance with the English, however, the marriage would take sometime to produce a surviving child until a daughter named Maria of Spain in June 25, 1525 was born, followed by a son named Philip on May 21, 1527, followed by two daughters, Catherine(December 2, 1528) and Joanna(June 26, 1535).

Catherine is intended for Afonso of Portugal the first son of the King of Portugal to further the matrimonial link between the Portuguese and the Spanish in the long run and Catherine is to marry the eldest son of the Holy Roman Emperor and Joanna is intended for a marriage treaty, those were the fates of the three daughters of Charles V.
Maria will be Empress or Queen of Portugal? You have given both weddings to Catherine...
 
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