Brandenburg-Poland union

Is it possible for the Margraviate of Brandenburg to unite with Poland under the Piasts(being granted by the HRE emperor or inherited maternally) or Hohenzollern, I know there are many instances that it could had happened, what if Poland and Brandenburg got united under a personal union before the Polish-Lithuanian union or when Poland and Lithuania can still be split, what would happen to the HRE and what would be it's possible consequences?
 
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Well, in the 1300s, Jadwiga of Hungary was supposed to marry Sigmisund, who was a luxembourgian king, and inherit what was Brandenburg at that point in time.
 
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