Saying that the Hussites destroyed Bohemia's economy, prosperity, etc. is like saying that Bismarck destroyed Germany's economy, prosperity, etc. by 1945. Sure, the Hussite Wars devastated Bohemia and the surrounding lands, but it was both the Hussites' and the Romanists' fault.
That said, the Hussites were a proto-nationalist/religious reformist movement, with the religious element predominant, as (we all know) the Church was in dire need of reform, what with the Avignon Papacy's legacy, the general selling out of Church positions, etc. In fact, the Hussites, as described by a number of my History Professors, were an early spark of the Reformation that died out mainly because of the Czech-German linguistic divide and the relative lack of printing presses that were very integral to the spread of the actual Reformation. If, somehow, somebody more lenient or more effective than Wenceslaus and Sigismund were in possession of the crown, the Hussites might well have simmered down, much like the Lollards. The actual effects of not having a Hussite period are, well, hard to predict. Bohemia might well have Germanicized earlier, or became locked more effectively into either Hungary or Poland's orbit.