You mean AND his brother Constantine. It was both of them that supposedly didn't want to have any man associated with the Imperial House. Personally I always found that odd, especially since Zoe was offered as a bride to Emperor Otto III. But if they both die and Zoe is married OTL yes I think its possible. It would be highly difficult and improbable but not impossible. Zoe would be 40 so a much better chance then she did at 50. Remember Constance of Sicily, Empress of Henry VI, gave birth to the future Frederick II at 40.