I vaguely remember reading a book about this premise. Astronaut's parents were Soviet sleeper agents, his early life was manipulated so he was bitter toward capitalism (falling in love then girl leaving him for some rich industrialist). I think he somehow takes control of shuttle, killing others on board.
Not sure about details but I think it ends along the lines of him landing in Soviet Union and then B-2 plane(s?) bomb the shit out of that airfield and destroy shuttle.
The Manchurian Astronaut...