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The history of Pre-Columbian America is often seen as less important due to the massive catastrophes of plague and conquest that nearly destroyed the world of the Aztecs, Inca and Mississippians. What I am asking is are there any good points of divergence before Columbus' s arrival, especially those relating to politics, culture and demographics, that would have a lasting effect on the history of America into the modern day.

Examples include

The Toltecs' decline is postponed.
The Tepanecs destroy Tenochtitlan.
The Mexica never migrate into the Valley of Mexico.
Waskar defeats Atawalpa.
The Xingu peoples develop an Inca level civilization.
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