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In the Spanish-American War the Teller Amendment and the Foraker Amendment prohibited the US from annexing Cuba and from granting US businesses concessions (although loopholes were eventually found). Do you think that without these the increased US investment and involvement in the Cuban economy would have been enough for an attempted annexation? The governor of Cuba, General Leonard Wood was heavily in favor of annexation and certainly in a position to make it favorable to US businesses especially if he isn't limited by the Foraker Amendment. If that's not enough how do you get the US to annex Cuba post-war?