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So Anne Neville is remembered as being - for all intents and purposes - Richard III's faceless queen (no proper portraits of her seem to survive), who's only son and heir died young and she followed him to the grave shortly after, followed by her husband months later.

What were the reasons (if any) why Anne never had any other children besides Edward of Middleham? Was she like Margaret Beaufort whose childlike body was torn apart by the birth of her only child - or was she simply unfortunate when compared to the Ceres-like fertility of Queen Elizabeth?

Is it possible that Anne was the victim of unmentioned/unchronicled miscarriages and stillbirths so characteristic of the age? Which does seem odd when one considers that she was the second/third lady of the court, but not unusual. Even Anne Boleyn, fifty years later, is an obstetrical mystery with three pregnancies that are dead-to-rights certain, but other pregnancies mentioned in letters by Chapuys and other sources at court that seem to be at odds with these dates.
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