While going through wikipedia, I found interesting POD.
In 1689, Bostonians imprisoned the Royal Governor and other sympathizers of King James II on April 18, 1689.
Now, this ended the de facto Dominion of New England. But, what if they hadn't done this, and remained the Dominion of New England? What effects would this have on them?
Another POD could be the British now adding New York and New Jersey to the Dominion. (In fact, It'd be interesting to see New England in possession of Long Island, where they were well accepted.)