I am pretty sure a non-nuclear power attacking a nuclear power head on, even when it is massively distracted is a very very suicidal idea. Basically everyone in Taiwan except Sheck wrote the PRC away after they tested their nuclear weapons.
Also the manner in which the rebellions are going on is very unrealistic.
I would like to point out that until the 1970 Chinese economic liberalization program, East Turkestan was one of the most loyal autonomous region in the PRC, and the ETIM was basically dead for two decades until it became revived in the late 70s and early 80s, before truly gaining traction in the late 90s. The East Turkestan People's Party was basically a few exiles in Moscow raving whilst the actual peoples in East Turkestan ignored them. And the rebellions. Much of the rebel 'controlled' territory is.....desert. Worthless lands where no one lived. The major cities all had several PRC garrisons of over 3,000 or 5,000 or at max 7,000-7,500 men all well equipped. This was done due to Xinjiang's closeness to India incase of a war between the PRC and India.
And the Tibetan uprisings. Tibetan independence is a whole lot more plausible here than the East Turkestan one you have written, however the places you have depicted are over 6500m himalayan mountain ranges. Also, Nepal has multiple places in the north which are tibetan majority and in 1965 told Mao that Nepal would enter any combat against Tibetan separatists. This will be interesting considering Nepal's independence guarantor and great power ally is Great Britain who supplied nepal with modern arms and equipment until the nepalese civil war.