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Was there a possibility of an alternative heir to the English Throne who was not Mary Queen of Scots or her son James?

I am assuming that it would be tricky for Elizabeth to produce a legitimate heir simply because of the consequences of marriage for a woman in that era.

I wonder just how big of a change preventing a union of crown would make?.

By the way how likely is Charles I of Scotland to produce a Civil war in that KingdoM
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