Ancient Macedonia being what it it, a weak with a strong kingdom will probably face a lot of coup attempts. Someone will try to gain control of and use that well-oiled war machine Philipp has created.
If your basic PoD is "no Macedonian+Greek war against Persia", then it might be the mest option to kill Alexander before he ever becomes king. Let's say that at Aigai, someone believes that Alexander had conspired with Pausanias to kill Philip II., and slays the prince in a fit of rage.
When Philip dies, Arrhidaios claims to be king as Philip III. The satrap of Caria might renew his offer to give him his daughter as wife.
Meanwhile, Attalus marching back the advance troops from Asia Minor to protect his niece, Philip II.s widow Cleopatra Eurydice and her two minor children, specially the boy Karanos. Demosthenes of Athens offers Athenian help to Attalus in exchange for Athenian freedom.
Meanwhile the former king deposed by Philip II., Amyntas IV is still alive and only 30 yo. He might see the situataion as fit for regaining his throne and title.
Just assume that the resulting free-for-all will end Macedonian capacity to keep Greece under its thumb and to make war on Persia for a generation.
Meanwhile, the League of Corinth is no more and Athens, Thebes and Sparta might go at it again.
Sparta might actually act as ally of Persia, and win this TL's version of Megalopolis. After all, without a defeat at Issos, persia will have more money to spare to support Agis III.
In Persia, AFAIK, Artashata/Darius III has the advantage of being the last legitimate scion of the Achaemenids. So a direct chalenge is unlikely, but satraps might choose to rebel regionally. We might certainly see a (short-lived?) 31st dynasty in Egypt before a Persian king or genral takes it back.
With a PoD in 336, Chandragupta Maurya is probably already born. He might still make himself master of the Nanda Empire and the Gangetic plain. A clash between a rising Maurya India and a Achaemenid Peria ofte the Indus area might be interesting.