AHC/WI: Republican JFK

Let's say the scion of the Kennedy family somehow turns red (or blue or whatever the colors were back then), turning away from his father's and grandfather's party. How would this happen? Would he still become President? Would he even be a congressman from Massachusetts? If so, what happens without Kennedy? What happens if Republican JFK wins the Presidency?
 
The problem is that the Northeast Republicans were a party for old money patricians and the Democrats were the party for the working class immigrant class. The Republicans were the party of the people who treated Joe Kennedy Sr. with disgust no matter how hard he worked or what he did.
 
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