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It was said that 1964 was the only time the Far-Right took over the Republican Party. It was said that 1972 was the only time the Far-Left took over the Democratic Party.
But, both times saw the parties lose in a landslide. Both candidates were painted as radicals and several members of their parties voted for the other. Both left their parties deeply divided as the establishment and moderates refused to support them. Both ran against popular incumbents. Both would be examples for their parties later on of what not to do.
Their names were Barry Goldwater and George McGovern. What if they ran against each other? Assuming the electorate is not favoring a certain party, such as 1960 or 2000.
Time frame could be 1960-1976. Both are running hard left or right. And neither are incumbents. No 3rd party.