AHC/WI: Fall of Granada before the Fall of Constantinople

The Fall of Granada (thus completing the Reconquista of the Iberian peninsula) and the Fall of Constantinople (thus ending the Byzantine Empire and cementing the Ottomans as a superpower of their day) were two of the most significant events of the 15th century. However...

1) With a POD no earlier than 1400, is it possible to switch the timing of the two events - that is, have the Reconquista be completed around 1450 or so, while Constantinople's fall takes place toward the end of the century?

2) What would be the likely effects of these events having switched place for the broad strokes of European and Middle Eastern politics, society, the Age of Discovery, etc?
 
1) Granada for its last century or two was a vassal state of Castile. It's certainly within the realm of plausibility to have the emirate fall a lot sooner. John II of Castile even assisted placing Yusuf on the throne; you could have John II deciding to abolish the emirate and impose direct rule on Granada. If you want something within the 1450s, have John II decide to reject the offer of a five year truce from Muhammad IX of Granada and invade the emirate, overthrowing the Nasirids and placing the last remaining Muslim holdout under Castilian rule.

I dunno about the New World being discovered earlier. I think if anything, it'll prompt the Castilians to continue the Reconquista in North Africa. Doubtful that they'd do any better beyond taking more coastal ports from whoever's in charge of Morocco.

2) Hard to say whether having the Ottoman assault on Constantinople in 1453 would give the Eastern Romans much more than a few more years of life. Say Mehmed is killed or the attack fails and Candarli Halil Pasha decides to take advantage of the situation and have Mehmed assassinated, replaced with his infant son Bayezid. The Byzantines release Orhan and likely with Venetian assistance, lends financial support to other Ottoman princelings and magnates to war amongst each other. This gives the Byzantines opportunity to make minor territorial concessions but it doesn't last. The Second Ottoman Interregnum merely delays the inevitable and the city falls to the Ottomans in 1500.
 
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