AHC: Weakest possible US

Assuming we keep at least the original 13 colonies together what is the weakest we could have seen the US by today? Meaning a much lessened economic and military influence than IOTL.
 
Assuming we keep at least the original 13 colonies together what is the weakest we could have seen the US by today? Meaning a much lessened economic and military influence than IOTL.

A U.S. comprised of only 7 of the original states, minus everything south of the *Mason-Dixon Line, would certainly be in a poor position, as would the opposite situation of an America comprised of only the 6 original U.S. states.
 
Fail to ratify the Constitution and allow any number of Western separatist conspiracies to work, perhaps by preventing Pinkney's Treaty from being ratified or even negotiated.
 
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