Could they somehow manage to gain and maintain control of Gibraltar? That's the only way I see them successfully being able to expand into the new world without being blocked by Spain.
There's no incentive for Venetians to seek an alternate trade route, they've already benefited from the existing trade route, that's why Columbus and other Italians like Cabot worked for Spain, Portugal and England.
There's no incentive for Venetians to seek an alternate trade route, they've already benefited from the existing trade route, that's why Columbus and other Italians like Cabot worked for Spain, Portugal and England.