AHC: US-Louisana War?

Is there any way with a POD during the 16th-18th centuries that by the 1800's a war between a young United States and Independent Louisiana occurs for whatever reasons?
 
Is there any way with a POD during the 16th-18th centuries that by the 1800's a war between a young United States and Independent Louisiana occurs for whatever reasons?

Im confused about the 16th century question in this thread (Given, that OTL United States didn´t exist in this century and the one afterwards).
Would this independent Lousiana (pre-sold) be French carholic dominated or would there be a cetratain rivaly with English speaking Settlers, on which behalf the US intervenes ? I could imagine some Andrew-Jackson-style-Florida raiding occur. What form of government would the independent Lousiania have ?
 
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