AHC:Screw the natives of the Americas worse.

I'm currently reading "A More Personal Union" which has as butterflies ended up with the Iroqouis ending up with some access to European technology and the Slaves of Cuba being helped in Revolt against the Spanish giving two native nations which are likely to get some level of respect (perhaps equivalent to Persia or India) in the European courts.

Wait, what?
 
The Black Death reaches them along with a doomed attempt at fleeing from Europe in the 14th century, as well as all the other diseases. Hilarity ensues.
 
If the bison went extinct with the other megafauna around fifteen thousand years ago, that could make it a little harder for the Plains tribes.
 
If the bison went extinct with the other megafauna around fifteen thousand years ago, that could make it a little harder for the Plains tribes.

That would butterfly away the Plains Indians as we know them, but the Apache tribes could still adopt horses and livestock, and take over the empty plains.

I assume you'd also want to apply this to the rheas of South America, who fed the Pampas Indians.
 
I don't think this is possible, given the scale of OTL-style destruction of the peoples and cultures involved in certain countries (including the USA) was near-total as it was).
 
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