One thing that intrigues me to this day is the so-called "Lost Colony" of Roanoke, which actually the first English settlement to be established (even earlier than both Jamestown and Plymouth). However, due to bad luck, poor planning, hostilities with the Spanish and of course the mysterious disappearance of the colonists (leaving behind just the carved words "Croatoan"), the colony pretty much failed.
Therefore, my question is how can the Roanoke Colony evade this fate and meet the same level of success that Jamestown was able to achieve? And what are the implications further down the road for the English/British colonies in the New World and beyond?