It's a crowded field of far better known, better connected, extremely able, and already regional or national figures ahead, several dozen men many of whom do become President, Vice President, Cabinet Officers, Constitutional Convention Delegates, War Heroes, Governors, etc. so Isaac would need a significant role in the Continental Congress, the Battle of Saratoga, New York's business world, and probably first elected/American governor of New York State to be in the running for President after Washington.
Heck his descendants are unlikely Presidents too, but both had served as Governors of New York, Undersecretary of the Navy, and other jobs they handled in a high profile way while Theodore had numerous books and articles to his fame as well as the much hyped Rough Riders' brief campaign.
Isaac's up against Adams, Jefferson, Madison, Monroe, Hamilton, Burr, Morris, Pinckney, Knox, Greene, Hancock, etc. rather than the weak candidates his descendants would run against.