Yes, obviously the topic is inspired by President Macron of France. I can't think of any parallel among serious presidential candidates in US history, and I wonder if anyone knows of any case where it might plausibly have happened. (A wife twenty-four years *younger*, as with Melania Trump, is another matter.) A few First Ladies were older than their husbands, but--except for Mrs. Harding--only by a year or two at most. "George Washington was 246 days younger than his wife, and Warren G. Harding was 5 years 78 days younger. Both Mrs. Washington and Mrs. Harding survived their husbands. Richard Nixon was 294 days younger than his wife, Benjamin Harrison was 322 days younger, and Millard Fillmore was younger by 1 year 299 days."
http://www.robinsonlibrary.com/america/unitedstates/presidents/marriage.htm.
I remember there was a bit of discussion about Bill Bradley's wife being older than him--but even that was only by eight years.
http://www.cnn.com/ALLPOLITICS/time/1999/09/27/ernestine.html
It is true that one POTUS-to-be did, like Macron, marry his teacher (or at least informal tutor, in that she taught her barely literate husband arithmetic and writing)
https://en.wikipedia.org/wiki/Eliza_McCardle_Johnson but she was actually a year younger than him...
(This obviously could go in either the pre-1900 or post-1900 section. I chose to put it in post-1900 because the nearest examples I could find--the Hardings and the Bradleys--were about post-1900 political careers.