If the Netherlands remains under Spanish control and without a revolt, the likelihood of Portugal revolting against the Habsburgs is also much lower. IOTL one of the major reasons for the revolt was the rescinding of the truce with the Netherlands in 1621. This made it so that the United Provinces attacked and occupied Northeastern Brazil, and attacked or blockaded Portuguese factories in the East. The result of this was that the Portuguese nobles and mercantile class began to see the entanglement of Spain's wars as an albatross around Portugal's commerce. Unlike nobles in many parts of Europe, those in Portugal were largely dependent on the colonial empire for their wealth, and Lisbon in particular suffered after attacks on Portuguese shipping from 1621 onwards. The request of Portugal to send troops to assist in the Catalan revolt was a major issue, but things might play out differently.
With a content Netherlands, the Antwerp will probably remain paramount as Northern Europe's principal port, and making it a major hub of trade with Baltic grain, naval stores, and furs passing through here, along with goods from the Indies and Castilian and English wool, Brazilian sugar, copper from Germany. Amsterdam would be relegated to the position of a smaller port, serving mostly Holland. The Habsburgs would have to have a somewhat enlightened policy of tolerance for the Netherlands, as it would be a very cosmopolitan region, with the major European banking houses based there.