With a POD this far back, well, under the Durazzo dynasty Naples had a fair chance at becoming a larger power and possibly unify Italy. The catch is that in this event, the capital is unlikely to remain at Naples.
However, I don't think that, with a suitable Late Medieval POD, some sort of dominance over much of modern Tunisia, Albania and Greece is out of question (of course this requires a severe curtailing of Ottoman power in its cradle, possible with the given time limits). Of course, if this is achieved by, say, 1500, is extremely unlikely to last to the present day.