In the European royal families of today, the claimed king of Portugal, Antonio has no descendants (ironic when you consider that he actually left a son that married and left ten children, versus various Renaissance popes who have heirs among various Catholic (and some Protestant) European royal families today). His battle was a constant uphill one - whether in proving his legitimacy or proving his right to the kingship. From what I can make out, D. Felipe II of Spain had the bulk of the aristocracy either well-bribed or well disposed to an Iberian Union, making Antonio's position more difficult. But, on the other hand, he had the support of England, France (and basically anyone who had a bone to pick with Spain) from time to time, yet still he failed.
His son, Manuel (II) married Emilia of Orange (sister of Maurits, Prince of Orange, Stadtholder of the Netherlands), and had ten children by her - including two sons - Manuel (III) and Luiz Guilherme, Duke of Guarda e Trancoso. However, as mentioned above, not even in the Portuguese royal family (which does descend from Pope Alexander VI) does he have descent. So, the challenge, is to make that his daughters - there were eight of them: Maria Belgica (1599-1647), Emilia Luiza (1605-1670), Ana Frisia (1606-1669), Juliana Caterina (1607-1680), Mauricia Leonor (1609-1674) and Sabina Delfica (1610-1670) (of whom Maria Emilia and Ana all married to unknown individuals, while Mauricia married in 1647 to the Count of Nassau-Siegen) - or his two sons (both of whom left children - Manuel (III) left four daughters, of whom two survived infancy, while Luiz left two sons, one of whom became an archbishop in the Spanish Netherlands.
Now while Antonio/Manuel (II) himself was a bastard, Portugal had accepted a bastard king before (Joao I), and Manuel had a legitimate marriage (although IDK about Emilia's religion being accepted in Portugal), so even his kids were to marry at the bottom of the totem pole (ironically, Alexander VI's royal descent (excepting those descending from Lucrezia), is either via his son, Juan, duke of Gandia or his daughter, Isabella (b.1471) who married a Pietro Matuzzi - and through him became the ancestress of the Mazarinettes; Cesare, the most famous child, has only in the last century found a royal descent in the current Carlist duke of Parma, who counts a Princess of Bourbon-Busset as a grandmother), they can still, via a circuitous route make their way into the royal bloodlines of Europe.
His son, Manuel (II) married Emilia of Orange (sister of Maurits, Prince of Orange, Stadtholder of the Netherlands), and had ten children by her - including two sons - Manuel (III) and Luiz Guilherme, Duke of Guarda e Trancoso. However, as mentioned above, not even in the Portuguese royal family (which does descend from Pope Alexander VI) does he have descent. So, the challenge, is to make that his daughters - there were eight of them: Maria Belgica (1599-1647), Emilia Luiza (1605-1670), Ana Frisia (1606-1669), Juliana Caterina (1607-1680), Mauricia Leonor (1609-1674) and Sabina Delfica (1610-1670) (of whom Maria Emilia and Ana all married to unknown individuals, while Mauricia married in 1647 to the Count of Nassau-Siegen) - or his two sons (both of whom left children - Manuel (III) left four daughters, of whom two survived infancy, while Luiz left two sons, one of whom became an archbishop in the Spanish Netherlands.
Now while Antonio/Manuel (II) himself was a bastard, Portugal had accepted a bastard king before (Joao I), and Manuel had a legitimate marriage (although IDK about Emilia's religion being accepted in Portugal), so even his kids were to marry at the bottom of the totem pole (ironically, Alexander VI's royal descent (excepting those descending from Lucrezia), is either via his son, Juan, duke of Gandia or his daughter, Isabella (b.1471) who married a Pietro Matuzzi - and through him became the ancestress of the Mazarinettes; Cesare, the most famous child, has only in the last century found a royal descent in the current Carlist duke of Parma, who counts a Princess of Bourbon-Busset as a grandmother), they can still, via a circuitous route make their way into the royal bloodlines of Europe.