Ah, Fort Wayne. Headquarters of Do it Best, my local hardware store.
OK, well, what was going on in that corner of Indiana? I'm thinking cars. Studebaker was in South Bend and they were big. Lasted through the mid 60s... Maybe if Studebaker or someone like it sets up shop in Fort Wayne, that can be a seed for a budding metropolis?
Regardless of how big it gets, if For Wayne is Indiana's largest city, it is indeed more of a Great lakes city like Chicago, Detroit and Cleveland as opposed to Indianapolis which is further inland. As such, Indiana's economic center will be closely tied with those cities. We also see a greater continuum of the urban metropolis from Buffalo to Milwaukee. Fort Wayne will be on a railroad line on the way to Chicago from the Eastern cities as well. Ion the other hand, the interior of Indiana languishes and the southern part of the state, which has far stronger ties to the Inland South (southern Indianans even have southern accents), will feel quite alienated. Overall, Indiana's social and political development mirrors Ohio but with more extreme divisions between urban and rural.