As everyone hopefully knows, Mary I, Queen of England (as well as her sis, Elizabeth) were at various times mentioned as possible wives for Edward Courtenay, 1e Earl of Devon (b.1526). But Devon was the son of the Marquess of Exeter by his SECOND wife, Gertrude Blount, whom he had married in 1519.
Exeter's FIRST wife was Elizabeth Grey, Viscountess Lisle whom he married in 1515. Now Liz Grey had formerly been the fiancée of Charles Brandon, duke of Suffolk, who had been created Viscount Lisle in right of his wife. However Little Brandon was the one doing the thinking, and Chaz married Mary Tudor the Elder instead. At which the countess of Devon (Henry VIII's aunt) got Liz's wardship and wed Liz to her son.
So, say Liz gives birth to a son in 1516/1517 (Henry, Viscount Lisle - I thought of naming him Edward but I wondered if Henry VIII - ever paranoid - wouldn't see that as the Courtenays emphasizing their royal pedigree SHOULD something happen to the king before he has a son) perhaps dying in childbirth to keep things more or less on an OTL track. Mary Tudor the Tounger is still born as OTL, and if Katherine of Aragon likewise fails to give Henry a son TTL (since she only had one pregnancy after Mary it's a 50-50 chance it'll be a boy, and then another 50-50 he won't go the same way as the dukes of Cornwall and Richmond and Edward VI).
Assuming things go as OTL (the birth of Lord Lisle would be a relatively minor POD which might not even have an outworking on things for a while). However, it does have an interesting effect on the issue and marriages of Liz Grey's heir (also named Liz Grey, Baroness Lisle), who wed first Edmund Dudley then Arthur Plantagenet, Henry VIII's uncle. Now, while the marriages will still happen (since both are before the POD), John Dudley (future duke of Northumberland) has no title to inherit.
Also, Anne Boleyn chose Gertrude, narchioness of Exeter as godmother to Elizabeth as a calculated snub (perhaps she still would), but Lord Lisle would be related to her through her mother. While Anne didn't LIKE all her relatives, Lord Lisle is probably too young to be much on her radar growing up. But if he's a good suck-up, Anne might be interested in arranging a good marriage for him once she is queen. Hell, I could even see her attempting to persuade Henry to humiliate Mary and marry HER to Lord Lisle.
Either way, I think it's a minor POD that could have interesting effects. Like the Dudley inheritance of the Lisle title, Brandon hanging onto the title in spite of not wedding the Viscountess. Anne Boleyn's Howard cousinage to Lord Lisle seeing him become a sort of protege at court, and how he'd be affected when she falls. The Exeter Conspiracy of 1538 etc etc
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