Habsburgs don't marry with Spanish kings and stay focused on Burgundy and Germany, eventually creating a German kingdom stretching from Boehemia to the Netherlands. England remains under House of York and wastes time fighting the French, so the Germans take the momentum in colonization.
A crusade taking advantage of an Ottoman civil war allows for Hungarians to create some puppet states in the Middle East and the Venetians to puppetize and later colonize Egypt, to later expand into India. Later, Venice unifies most of Italy. With welath flowing in Italy, both Florence and Genua try to find new markets not controlled by Venice and end up settling colonies in America, taking the natives under suzerainity.
Poland defeats Russians and Turks, partitioning the area with Swedes, who are allied due to a post-Charles V's Habsburg like "double-dinasty", and go eastward, eventually building a Uber-Poland stretching to Siberia and Alaska !
So, you have a divided Italy superpower, Poland which gobbles up Russia, creates Canada and probably is the world superpower

, and United States of New Germany on the North Eastern Coast ! I don't know how Hungary could control something in the new world, but the idea of Hungarian oil bosses toppling regimes in the Middle East is cool