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The Italian Wars stretched from 1494 until 1559 and involved almost ever significant power in Europe at one time or another. In the end the Habsburgs emerged victorious and they would remain the dominant power in Italy for centuries after.

My challenge/question is if and at what point in time the French could plausibly emerge victorious in these conflicts. By victorious i mean to a similar degree to what the Habsburgs were able to achieve i.e. control of the majority of the peninsula. Any lesser degree of success would be interesting as well.

Additionally, I was wondering what some of the impacts of this would be for all the involved powers. How does this change the marriage calculus for the Valois and Habsburg dynasties. Can a single person rule both Spain and the HRE without control of Naples and the Mediterranean Islands. So on and so forth.
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