With a POD no earlier than 600 B.C. and no later than 500 B.C., turn the Etruscans into the uber-power in Europe by 1 A.D. and turn Rome into at least a vassal state, at most a burned skeleton of a city.
Well, one obvious PoD would be for the Capuan Etruscans to defeat the alliance led by the Greek colony of Cumae (ruled by the tyrant Aristodemus) in 524 BCE instead of being defeated. It was after this that Etruscan power began to seriously diminish. 15 years later, in 509 BCE, Rome overthrew its Etruscan monarchy and instituted a republic, and I am sure that one factor was the reduced prestige of the Etruscans in general.