I count it by the Dead of Charles II, the End of the Thirty years war was a blow but not a irremediable one, and in this time Spain was still in possession of the Spanish Netherlands; after the Dead of Charles, The War of the Spanish Succession, the lost of the Netherlands to France, England, Netherlands and finally Austria, The lost of the Influence over Italy, the close of the Spanish road, is the final death sentence.
It was over by the War of Devolution. The fact that England, the Dutch (!) and Sweden were willing to ally with Spain against France showed that the balance of power had now changed.
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