AHC/Discussion: Kill the United States past 1783

Ive been poking at ideas for a TL, and an idea that's interested me for a while is how fragile early America was.

My question to you is what are the worst case scenarios that an early US could suffer post-Revolution?
 
Well there was a story where the Whiskey Rebellion overthrew the Government and made us a nation governed by unanimous consent.
 
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