Have the Eastern World (Anatolia and everything East of it) become the dominant but declining world powers and have the Western World be the rising underdog that would ultimately eclipse the East.
In short, its like reversing China and the United States' position today: one stagnant superpower and one potential superpower
You may use ANY combination of PoDs to make this plausible
I am aware that the East, for centuries, dominated the world.
Bonus Points:
Asian AND European Americas
Have an Indian or Chinese EU (if you choose to balkanize those countries)
No communism
Keeping Islam in the Arabian peninsula.